Altered Erythrocyte CR1 Binding Kinetics Compensate for Decreased Binding Capacity in Rheumatoid Arthritis

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Serum concanavalin-A binding in rheumatoid arthritis.

A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in patients with active RA. Twenty-four patients were treated for 6 months with D-...

متن کامل

Native DNA binding in rheumatoid arthritis.

With the introduction of the ammonium sulphate precipitation (Farr) technique, a sensitive procedure for the detection of antibodies to either native deoxyribonucleic acid (nDNA) or heat-denatured singlestranded deoxyribonucleic acid (sDNA) has become available (Wold, Young, Tan, and Farr, 1968). Furthermore, quantitation of the amount of antibody present in the test serum can be expressed with...

متن کامل

Abnormal osteocalcin binding in rheumatoid arthritis.

Studies of osteocalcin in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) showed the presence of significant amounts of osteocalcin in synovial fluid and that the values in RA synovial fluid were significantly lower than in OA synovial fluid. In addition, the osteocalcin in OA synovial fluid bound almost completely to hydroxyapatite, whereas a sig...

متن کامل

Calcium binding capacity of erythrocyte membrane in human hypertension.

The cell membrane calcium binding capacity of genetically hypertensive rats is reduced when measured in the presence of the submicromolar calcium concentrations proper of intracellular environment. The present work, performed as an ancillary study to an epidemiological survey on an entire population, aimed to investigate the existence of a similar abnormality in human hypertension. Calcium bind...

متن کامل

The primate erythrocyte complement receptor (CR1) as a privileged site: binding of immunoglobulin G to erythrocyte CR1 does not target erythrocytes for phagocytosis.

The primate erythrocyte (E) complement receptor, CR1, is a transmembrane glycoprotein located in clusters on the surface of E. In vivo studies have demonstrated that during processing and clearance of complement-opsonized immune complexes, large amounts of immunoglobulin G (IgG) can be bound to primate E via CR1 with no E loss or lysis. However, when comparable amounts of IgG are bound to other...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Clinical Chemistry and Laboratory Medicine

سال: 1990

ISSN: 1434-6621,1437-4331

DOI: 10.1515/cclm.1990.28.8.533